Studying the effect of white matter hyperintensities in different brain regions
  
   Lead Investigator:    Mahsa Dadar
   Institution      :    Studying the effect of white matter hyperintensiti
   E-Mail           :    mahsa.dadar@gmail.com
   Proposal ID      :    820


   Publications:


1  Dadar M, Maranzano J, Misquitta K, Anor CJ, Fonov VS, Tartaglia AC, Carmichael O, DeCarli C, Collins DL
   Performance Comparison of 10 Different Classification Techniques in Segmenting White Matter Hyperintensities in Aging
   Journal Article  Neuroimage,157:233-249,2017,PMC6469398

   PUBLISHED





   Proposal Description:
   We are planning to automatically segment the white matter hyperintensities from   structural MRIs of the subjects and correlate them with different measures of     cognition to investigate if the location and load of white matter                 hyperintenisities are different between cohorts with different types of           dementia. We need MRI, demographic and neurocog/neuropsych data to                      1- characterize and quantify white matter hyperintensities in the NACC      data                                                                                    2- apply our tools for structure segmentation (hippocampus, amygdala,       entorhinal cortex, etc.)                                                                3- use longitudinal data to create trajectories of structure volumes over   time, and to identify                                                                   differences between normal aging,  AD, LBD, VD, FTLD (behavioural, with     PPA and other), and                                                                     TBI (as an aide to differential diagnosis).                                       4- We are also looking for early morphological changes associated with      SCI.